Therapeutic alternatives for the treatment of ocular inflammatory diseases
- Xurxo García Otero
- Francisco Javier Otero Espinar Director
- Anxo Fernández Ferreiro Director/a
- Pablo Aguiar Fernández Director
- José Blanco Méndez Director
Universidad de defensa: Universidade de Santiago de Compostela
Año de defensa: 2022
Tipo: Tesis
Resumen
In the present thesis, different formulations of tacrolimus for topical-ophthalmic administration have been proposed, supported by extensive preclinical studies in order to achieve a consistent basis for the treatment of ocular inflammatory diseases. On the other hand, a pharmacokinetic and distribution study of an anti-TNFα monoclonal antibody (adalimumab) injected intravitreally was also carried out, allowing to know its behavior in the eye and thus develop new administration systems.