Therapeutic alternatives for the treatment of ocular inflammatory diseases

  1. García Otero, Xurxo
Supervised by:
  1. Francisco Javier Otero Espinar Director
  2. Anxo Fernández Ferreiro Director
  3. Pablo Aguiar Fernández Director
  4. José Blanco Méndez Director

Defence university: Universidade de Santiago de Compostela

Year of defence: 2022

Department:
  1. Department of Pharmacology, Pharmacy and Pharmaceutical Technology

Type: Thesis

Abstract

In the present thesis, different formulations of tacrolimus for topical-ophthalmic administration have been proposed, supported by extensive preclinical studies in order to achieve a consistent basis for the treatment of ocular inflammatory diseases. On the other hand, a pharmacokinetic and distribution study of an anti-TNFα monoclonal antibody (adalimumab) injected intravitreally was also carried out, allowing to know its behavior in the eye and thus develop new administration systems.