Therapeutic alternatives for the treatment of ocular inflammatory diseases
- Francisco Javier Otero Espinar Doktorvater
- Anxo Fernández Ferreiro Doktorvater/Doktormutter
- Pablo Aguiar Fernández Doktorvater
- José Blanco Méndez Doktorvater
Universität der Verteidigung: Universidade de Santiago de Compostela
Jahr der Verteidigung: 2022
Art: Dissertation
Zusammenfassung
In the present thesis, different formulations of tacrolimus for topical-ophthalmic administration have been proposed, supported by extensive preclinical studies in order to achieve a consistent basis for the treatment of ocular inflammatory diseases. On the other hand, a pharmacokinetic and distribution study of an anti-TNFα monoclonal antibody (adalimumab) injected intravitreally was also carried out, allowing to know its behavior in the eye and thus develop new administration systems.