Therapeutic alternatives for the treatment of ocular inflammatory diseases

  1. Xurxo García Otero
unter der Leitung von:
  1. Francisco Javier Otero Espinar Doktorvater
  2. Anxo Fernández Ferreiro Doktorvater/Doktormutter
  3. Pablo Aguiar Fernández Doktorvater
  4. José Blanco Méndez Doktorvater

Universität der Verteidigung: Universidade de Santiago de Compostela

Jahr der Verteidigung: 2022

  1. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica

Art: Dissertation


In the present thesis, different formulations of tacrolimus for topical-ophthalmic administration have been proposed, supported by extensive preclinical studies in order to achieve a consistent basis for the treatment of ocular inflammatory diseases. On the other hand, a pharmacokinetic and distribution study of an anti-TNFα monoclonal antibody (adalimumab) injected intravitreally was also carried out, allowing to know its behavior in the eye and thus develop new administration systems.