DNA recognition with self-assembled peptide helicates

  1. Jacobo Gómez González
Dirixida por:
  1. M. Eugenio Vázquez Director
  2. Miguel Vázquez López Director

Universidade de defensa: Universidade de Santiago de Compostela

Ano de defensa: 2020

  1. María Jesus Macías Hernández Presidente/a
  2. Félix Manuel Freire Iribarne Secretario
  3. Angelo Taglietti Vogal
  1. Departamento de Química Orgánica

Tipo: Tese


Helicates, first described by Prof. Jean-Marie Lehn more than twenty years ago, display promising antimicrobial and antitumoral effects, but despite their compelling biological properties, the development of helicates into viable chemotherapeutic agents has been hampered by the lack of versatile and efficient stereoselective synthetic methods. In this thesis we describe the application of non-natural peptides containing the 2,2´-bipyridine ligand as platforms for the programmed self-assembly of DNA-binding metallopeptide helicates.