DNA recognition with self-assembled peptide helicates

  1. Gómez González, Jacobo
Supervised by:
  1. M. Eugenio Vázquez Director
  2. Miguel Vázquez López Director

Defence university: Universidade de Santiago de Compostela

Fecha de defensa: 17 April 2020

Committee:
  1. María Jesus Macías Hernández Chair
  2. Félix Manuel Freire Iribarne Secretary
  3. Angelo Taglietti Committee member
Department:
  1. Department of Organic chemistry

Type: Thesis

Teseo: 620694 DIALNET lock_openOpen access editor

Abstract

Helicates, first described by Prof. Jean-Marie Lehn more than twenty years ago, display promising antimicrobial and antitumoral effects, but despite their compelling biological properties, the development of helicates into viable chemotherapeutic agents has been hampered by the lack of versatile and efficient stereoselective synthetic methods. In this thesis we describe the application of non-natural peptides containing the 2,2´-bipyridine ligand as platforms for the programmed self-assembly of DNA-binding metallopeptide helicates.