DNA recognition with self-assembled peptide helicates
- Marco Eugenio Vázquez Sentís Doktorvater
- Miguel Vázquez López Doktorvater
Universität der Verteidigung: Universidade de Santiago de Compostela
Fecha de defensa: 17 von April von 2020
- María Jesus Macías Hernández Präsident/in
- Félix Manuel Freire Iribarne Sekretär
- Angelo Taglietti Vocal
Art: Dissertation
Zusammenfassung
Helicates, first described by Prof. Jean-Marie Lehn more than twenty years ago, display promising antimicrobial and antitumoral effects, but despite their compelling biological properties, the development of helicates into viable chemotherapeutic agents has been hampered by the lack of versatile and efficient stereoselective synthetic methods. In this thesis we describe the application of non-natural peptides containing the 2,2´-bipyridine ligand as platforms for the programmed self-assembly of DNA-binding metallopeptide helicates.