On the search for multitarget inhibitors for BACE‐1 and other pharmacological targets of Alzheimer's Disease
- Domínguez Meijide, José Luís
- María del Carmen Villaverde Cameron-Walker Director
- Fredy Sussman Co-director
- Ramón José Estévez Cabanas Co-director
Universidade de defensa: Universidade de Santiago de Compostela
Fecha de defensa: 11 de xullo de 2014
- Ferran Sanz Carreras Presidente/a
- María de los Angeles Castro Pérez Secretaria
- Angelo Carotti Vogal
- Leonardo Pardo Carrasco Vogal
- Francisco Javier Sardina López Vogal
Tipo: Tese
Resumo
Alzheimer disease (AD) is a devastating illness that affects populations worldwide, and for which an effective cure has yet to be found. We have studied in depth the effect of various factors like pH and ligand structure on the inhibition of BACE-1, one of the enzymes that produce the Aβ peptides, whose aggregation is a hallmark of this disease. The results of this study helped us to obtain drug leads that inhibit not only the aforementioned enzyme but some other AD therapeutic targets at the core of this illness. This study successfully identified several compounds with true multitarget potential against AD at the amyloidogenic and cholinergic levels.