On the search for multitarget inhibitors for BACE‐1 and other pharmacological targets of Alzheimer's Disease
- Domínguez Meijide, José Luís
- María del Carmen Villaverde Cameron-Walker Doktormutter
- Fredy Sussman Co-Doktorvater
- Ramón José Estévez Cabanas Co-Doktorvater
Universität der Verteidigung: Universidade de Santiago de Compostela
Fecha de defensa: 11 von Juli von 2014
- Ferran Sanz Carreras Präsident/in
- María de los Angeles Castro Pérez Sekretärin
- Angelo Carotti Vocal
- Leonardo Pardo Carrasco Vocal
- Francisco Javier Sardina López Vocal
Art: Dissertation
Zusammenfassung
Alzheimer disease (AD) is a devastating illness that affects populations worldwide, and for which an effective cure has yet to be found. We have studied in depth the effect of various factors like pH and ligand structure on the inhibition of BACE-1, one of the enzymes that produce the Aβ peptides, whose aggregation is a hallmark of this disease. The results of this study helped us to obtain drug leads that inhibit not only the aforementioned enzyme but some other AD therapeutic targets at the core of this illness. This study successfully identified several compounds with true multitarget potential against AD at the amyloidogenic and cholinergic levels.