Publications (60) MARIA DE LOS ANGELES CASTRO PEREZ publications

2024

  1. 2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives

    Molecules, Vol. 29, Núm. 11

  2. Discovery and in vitro Evaluation of Novel Serotonin 5-HT2A Receptor Ligands Identified Through Virtual Screening

    ChemMedChem

2023

  1. Development and Characterization of Novel Selective, Non-Basic Dopamine D2 Receptor Antagonists for the Treatment of Schizophrenia

    Molecules, Vol. 28, Núm. 10

  2. Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents – Design, synthesis, structural studies and pharmacological profiling

    European Journal of Medicinal Chemistry, Vol. 252

  3. Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation

    Journal of enzyme inhibition and medicinal chemistry, Vol. 38, Núm. 1, pp. 2209828

  4. Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons

    International Journal of Molecular Sciences, Vol. 24, Núm. 18

2022

  1. Allosteric modulation of dopamine D2L receptor in complex with Gi1 and Gi2 proteins: the effect of subtle structural and stereochemical ligand modifications

    Pharmacological Reports, Vol. 74, Núm. 2, pp. 406-424

  2. An Experience of Using a Canvas-Based Template for Blended-Learning in a Master in Drug Discovery

    International Journal of Emerging Technologies in Learning, Vol. 17, Núm. 6, pp. 257-267

  3. Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties

    Molecules, Vol. 27, Núm. 4

  4. In vitro and in vivo evaluation of antioxidant and neuroprotective properties of antipsychotic D2AAK1

    Neurochemical Research, Vol. 47, Núm. 6, pp. 1778-1789

  5. Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety

    ChemMedChem, Vol. 17, Núm. 15

2021

  1. Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder

    ACS Chemical Neuroscience, Vol. 12, Núm. 8, pp. 1313-1327

  2. N-(3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}propyl)-1H-indazole-3-carboxamide (D2AAK3) as a potential antipsychotic: In vitro, in silico and in vivo evaluation of a multi-target ligand

    Neurochemistry International, Vol. 146

2020

  1. 1-(2′-Bromobenzyl)-6,7-dihydroxy- N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D2 Dopamine Receptors

    Journal of Natural Products, Vol. 83, Núm. 1, pp. 127-133

  2. Essential role of the C148–C227 disulphide bridge in the human 5-HT2A homodimeric receptor

    Biochemical Pharmacology, Vol. 177

  3. N-(2-hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1h-benzimidazol-1-yl)propyl]piperidine-4-carboxamide (d2aak4), a multi-target ligand of aminergic gpcrs, as a potential antipsychotic

    Biomolecules, Vol. 10, Núm. 2

  4. New serotoninergic ligands containing indolic and methyl indolic nuclei: Synthesis and in vitro pharmacological evaluation

    Medicinal Chemistry, Vol. 16, Núm. 4, pp. 517-530

2019

  1. 2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenosine receptor antagonists: Synthesis and structure-activity relationships

    Bioorganic and Medicinal Chemistry, Vol. 27, Núm. 16, pp. 3551-3558

  2. Phenolic imidazole derivatives with dual antioxidant/antifungal activity: Synthesis and structure-activity relationship

    Medicinal Chemistry, Vol. 15, Núm. 4, pp. 341-351

  3. Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs

    European Journal of Medicinal Chemistry, Vol. 180, pp. 673-689