Publicacións (60) Publicacións de MARIA DE LOS ANGELES CASTRO PEREZ

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2025

  1. Synthesis, Experimental and Computational Evaluation of SERAAK1 as a 5-HT2A Receptor Ligand

    Molecules, Vol. 30, Núm. 10

2024

  1. 2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives

    Molecules, Vol. 29, Núm. 11

  2. Discovery and in vitro Evaluation of Novel Serotonin 5-HT2A Receptor Ligands Identified Through Virtual Screening

    ChemMedChem, Vol. 19, Núm. 14

2023

  1. Development and Characterization of Novel Selective, Non-Basic Dopamine D2 Receptor Antagonists for the Treatment of Schizophrenia

    Molecules, Vol. 28, Núm. 10

  2. Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents – Design, synthesis, structural studies and pharmacological profiling

    European Journal of Medicinal Chemistry, Vol. 252

  3. Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation

    Journal of enzyme inhibition and medicinal chemistry, Vol. 38, Núm. 1, pp. 2209828

2022

  1. Allosteric modulation of dopamine D2L receptor in complex with Gi1 and Gi2 proteins: the effect of subtle structural and stereochemical ligand modifications

    Pharmacological Reports, Vol. 74, Núm. 2, pp. 406-424

  2. An Experience of Using a Canvas-Based Template for Blended-Learning in a Master in Drug Discovery

    International Journal of Emerging Technologies in Learning, Vol. 17, Núm. 6, pp. 257-267

  3. Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties

    Molecules, Vol. 27, Núm. 4

  4. In vitro and in vivo evaluation of antioxidant and neuroprotective properties of antipsychotic D2AAK1

    Neurochemical Research, Vol. 47, Núm. 6, pp. 1778-1789

  5. Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety

    ChemMedChem, Vol. 17, Núm. 15

2021

  1. Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder

    ACS Chemical Neuroscience, Vol. 12, Núm. 8, pp. 1313-1327

  2. N-(3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}propyl)-1H-indazole-3-carboxamide (D2AAK3) as a potential antipsychotic: In vitro, in silico and in vivo evaluation of a multi-target ligand

    Neurochemistry International, Vol. 146

2020

  1. 1-(2′-Bromobenzyl)-6,7-dihydroxy- N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D2 Dopamine Receptors

    Journal of Natural Products, Vol. 83, Núm. 1, pp. 127-133

  2. Essential role of the C148–C227 disulphide bridge in the human 5-HT2A homodimeric receptor

    Biochemical Pharmacology, Vol. 177

  3. N-(2-hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1h-benzimidazol-1-yl)propyl]piperidine-4-carboxamide (d2aak4), a multi-target ligand of aminergic gpcrs, as a potential antipsychotic

    Biomolecules, Vol. 10, Núm. 2

  4. New serotoninergic ligands containing indolic and methyl indolic nuclei: Synthesis and in vitro pharmacological evaluation

    Medicinal Chemistry, Vol. 16, Núm. 4, pp. 517-530

2019

  1. 2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenosine receptor antagonists: Synthesis and structure-activity relationships

    Bioorganic and Medicinal Chemistry, Vol. 27, Núm. 16, pp. 3551-3558

  2. Phenolic imidazole derivatives with dual antioxidant/antifungal activity: Synthesis and structure-activity relationship

    Medicinal Chemistry, Vol. 15, Núm. 4, pp. 341-351

  3. Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs

    European Journal of Medicinal Chemistry, Vol. 180, pp. 673-689