
MARIA DE LOS ANGELES
CASTRO PEREZ
Profesora titular de universidade
Publicacións (54)
2022
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Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety
ChemMedChem, Vol. 17, Núm. 15
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In vitro and in vivo evaluation of antioxidant and neuroprotective properties of antipsychotic D2AAK1
Neurochemical Research, Vol. 47, Núm. 6, pp. 1778-1789
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Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties
Molecules, Vol. 27, Núm. 4
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An Experience of Using a Canvas-Based Template for Blended-Learning in a Master in Drug Discovery
International Journal of Emerging Technologies in Learning, Vol. 17, Núm. 6, pp. 257-267
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Allosteric modulation of dopamine D2L receptor in complex with Gi1 and Gi2 proteins: the effect of subtle structural and stereochemical ligand modifications
Pharmacological Reports, Vol. 74, Núm. 2, pp. 406-424
2021
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N-(3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}propyl)-1H-indazole-3-carboxamide (D2AAK3) as a potential antipsychotic: In vitro, in silico and in vivo evaluation of a multi-target ligand
Neurochemistry International, Vol. 146
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Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder
ACS Chemical Neuroscience, Vol. 12, Núm. 8, pp. 1313-1327
2020
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New serotoninergic ligands containing indolic and methyl indolic nuclei: Synthesis and in vitro pharmacological evaluation
Medicinal Chemistry, Vol. 16, Núm. 4, pp. 517-530
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N-(2-hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1h-benzimidazol-1-yl)propyl]piperidine-4-carboxamide (d2aak4), a multi-target ligand of aminergic gpcrs, as a potential antipsychotic
Biomolecules, Vol. 10, Núm. 2
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Essential role of the C148–C227 disulphide bridge in the human 5-HT2A homodimeric receptor
Biochemical Pharmacology, Vol. 177
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1-(2′-Bromobenzyl)-6,7-dihydroxy- N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D2 Dopamine Receptors
Journal of Natural Products, Vol. 83, Núm. 1, pp. 127-133
2019
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Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs
European Journal of Medicinal Chemistry, Vol. 180, pp. 673-689
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Phenolic imidazole derivatives with dual antioxidant/antifungal activity: Synthesis and structure-activity relationship
Medicinal Chemistry, Vol. 15, Núm. 4, pp. 341-351
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2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenosine receptor antagonists: Synthesis and structure-activity relationships
Bioorganic and Medicinal Chemistry, Vol. 27, Núm. 16, pp. 3551-3558
2018
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Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D₂ Receptor Ligand
Molecules (Basel, Switzerland), Vol. 23, Núm. 9
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New nitrogen compounds coupled to phenolic units with antioxidant and antifungal activities: Synthesis and structure-activity relationship
Molecules, Vol. 23, Núm. 10
2017
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Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization
European Journal of Pharmacology, Vol. 815, pp. 138-146
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Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors
Scientific Reports, Vol. 7, Núm. 1
2016
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Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins
Scientific Reports, Vol. 6
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8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease
ChemistrySelect, Vol. 1, Núm. 11, pp. 2742-2749