BioFarma
Bioloxía de membranas e mecanismos de transducción de sinais en farmacoloxía aplicada.
Publikationen (383) Publikationen, an denen Forscher/innen teilgenommen haben
2024
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Design, synthesis and validation of a new Crimped Head-Piece for DNA-Encoded libraries generation
Bioorganic and Medicinal Chemistry, Vol. 99
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Effect of Bulky N-Dibenzofuranylmethyl Substitution on the 5-HT2 Receptor Affinity and Efficacy of a Psychedelic Phenethylamine
ACS Chemical Neuroscience, Vol. 15, Núm. 3, pp. 608-616
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Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents
Biomedicine and Pharmacotherapy, Vol. 173
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High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries
SLAS Discovery, Vol. 29, Núm. 3
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In vitro models for neuropathic pain phenotypic screening in brain therapeutics
Pharmacological Research, Vol. 202
2023
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8-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studies
European Journal of Medicinal Chemistry, Vol. 248
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A Robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery
Molecules, Vol. 28, Núm. 24
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A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry
Archives of Toxicology, Vol. 97, Núm. 4, pp. 1091-1111
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Design and biopharmaceutical preclinical characterisation of a new thermosensitive hydrogel for the removal of gastric polyps
International Journal of Pharmaceutics, Vol. 635, pp. 122706
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Development and Characterization of Novel Selective, Non-Basic Dopamine D2 Receptor Antagonists for the Treatment of Schizophrenia
Molecules, Vol. 28, Núm. 10
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Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase
Journal of Medicinal Chemistry, Vol. 66, Núm. 1, pp. 235-250
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Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents – Design, synthesis, structural studies and pharmacological profiling
European Journal of Medicinal Chemistry, Vol. 252
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Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists
Communications biology, Vol. 6, Núm. 1, pp. 376
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Exploring the Effect of Halogenation in a Series of Potent and Selective A2BAdenosine Receptor Antagonists
Journal of Medicinal Chemistry, Vol. 66, Núm. 1, pp. 890-912
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Fluorescence based HTS-compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells
Frontiers in Molecular Biosciences, Vol. 10
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N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R)
European Journal of Medicinal Chemistry, Vol. 248
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Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation
Journal of enzyme inhibition and medicinal chemistry, Vol. 38, Núm. 1, pp. 2209828
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Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction
Bioorganic and Medicinal Chemistry, Vol. 84
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Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons
International Journal of Molecular Sciences, Vol. 24, Núm. 18
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Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Nature Communications, Vol. 14, Núm. 1