Nanoengineered delivery of RNAimpact on brain diseases and COVID-19 vaccination

  1. López Borrajo, Mireya
Dirigida por:
  1. María José Alonso Fernández Directora

Universidad de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 22 de diciembre de 2023

Tribunal:
  1. Bruno Filipe Carmelino Cardoso Sarmento Presidente/a
  2. María Dolores Torres López Secretario/a
  3. Maria Jesús Vicent Docon Vocal
Departamento:
  1. Departamento de Farmacología, Farmacia y Tecnología Farmacéutica

Tipo: Tesis

Teseo: 830208 DIALNET lock_openMINERVA editor

Resumen

Genetic therapies show great potential for treating various diseases through modulation of the expression of specific genes. Their effective delivery is crucial, particularly for challenging conditions like CNS diseases and SARS-CoV-2 vaccines. Here, we used nanotechnology as a fundamental tool for RNA delivery. First, we engineered an ionizable nanoemulsion designed for brain diffusion and delivery of RNA. Second, we explored nanocarriers loaded with siRNA for brain delivery, exploring their performance following alternative administration routes. Finally, we encapsulated mRNAs derived from SARS-CoV-2 within nanoemulsions and polymeric nanocapsules, achieving significant cellular immune responses.