Nanoengineered delivery of RNAimpact on brain diseases and COVID-19 vaccination

  1. López Borrajo, Mireya
unter der Leitung von:
  1. María José Alonso Fernández Doktormutter

Universität der Verteidigung: Universidade de Santiago de Compostela

Fecha de defensa: 22 von Dezember von 2023

  1. Bruno Filipe Carmelino Cardoso Sarmento Präsident/in
  2. María Dolores Torres López Sekretär/in
  3. Maria Jesús Vicent Docon Vocal
  1. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica

Art: Dissertation


Genetic therapies show great potential for treating various diseases through modulation of the expression of specific genes. Their effective delivery is crucial, particularly for challenging conditions like CNS diseases and SARS-CoV-2 vaccines. Here, we used nanotechnology as a fundamental tool for RNA delivery. First, we engineered an ionizable nanoemulsion designed for brain diffusion and delivery of RNA. Second, we explored nanocarriers loaded with siRNA for brain delivery, exploring their performance following alternative administration routes. Finally, we encapsulated mRNAs derived from SARS-CoV-2 within nanoemulsions and polymeric nanocapsules, achieving significant cellular immune responses.