Nanocapsules containing immunomodulators and monoclonal antibodies for the treatment of lung cancer

  1. Berrecoso Cuña, Germán
Dirixida por:
  1. María José Alonso Fernández Director
  2. José Crecente Campo Director

Universidade de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 02 de xaneiro de 1963

Tribunal:
  1. Avi Schroeder Presidente/a
  2. Marcos García Fuentes Secretario
  3. Cristina Fornaguera Puigvert Vogal
Departamento:
  1. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica

Tipo: Tese

Teseo: 785253 DIALNET lock_openAcceso aberto editor

Resumo

The main objectives of this thesis were, first, to characterize the chemical, physicochemical, and biological composition following the Minimum Information about Nanomaterial Biocorona Experiments (MINBE) recommendations of blank polymeric NCs, second, to develop NCs loaded with chemotherapeutics and immunomodulators (STAT3 and TGF-β pathway inhibitors), and third, to develop a nanotechnology platform for the intracellular delivery of mAb (bevacizumab as a model mAb, and anti-KRASG12V mAb as therapeutic mAb).