Nanocapsules containing immunomodulators and monoclonal antibodies for the treatment of lung cancer

  1. Berrecoso Cuña, Germán
unter der Leitung von:
  1. María José Alonso Fernández Doktormutter
  2. José Crecente Campo Doktorvater/Doktormutter

Universität der Verteidigung: Universidade de Santiago de Compostela

Fecha de defensa: 02 von Januar von 1963

Gericht:
  1. Avi Schroeder Präsident/in
  2. Marcos García Fuentes Sekretär
  3. Cristina Fornaguera Puigvert Vocal
Fachbereiche:
  1. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica

Art: Dissertation

Teseo: 785253 DIALNET lock_openMINERVA editor

Zusammenfassung

The main objectives of this thesis were, first, to characterize the chemical, physicochemical, and biological composition following the Minimum Information about Nanomaterial Biocorona Experiments (MINBE) recommendations of blank polymeric NCs, second, to develop NCs loaded with chemotherapeutics and immunomodulators (STAT3 and TGF-β pathway inhibitors), and third, to develop a nanotechnology platform for the intracellular delivery of mAb (bevacizumab as a model mAb, and anti-KRASG12V mAb as therapeutic mAb).