Nanocapsules containing immunomodulators and monoclonal antibodies for the treatment of lung cancer

  1. Berrecoso Cuña, Germán
Supervised by:
  1. María José Alonso Fernández Director
  2. José Crecente Campo Director

Defence university: Universidade de Santiago de Compostela

Fecha de defensa: 02 January 1963

Committee:
  1. Avi Schroeder Chair
  2. Marcos García Fuentes Secretary
  3. Cristina Fornaguera Puigvert Committee member
Department:
  1. Department of Pharmacology, Pharmacy and Pharmaceutical Technology

Type: Thesis

Teseo: 785253 DIALNET lock_openMINERVA editor

Abstract

The main objectives of this thesis were, first, to characterize the chemical, physicochemical, and biological composition following the Minimum Information about Nanomaterial Biocorona Experiments (MINBE) recommendations of blank polymeric NCs, second, to develop NCs loaded with chemotherapeutics and immunomodulators (STAT3 and TGF-β pathway inhibitors), and third, to develop a nanotechnology platform for the intracellular delivery of mAb (bevacizumab as a model mAb, and anti-KRASG12V mAb as therapeutic mAb).