Research and development of advanced controlled drug delivery systemsapplication in Keratoconus and Leber´s Hereditary Optic Neuropathy

  1. Rubén Varela Fernández
Dirixida por:
  1. Francisco Javier Otero Espinar Director
  2. Isabel Lema Gesto Director
  3. Miguel González Barcia Director

Universidade de defensa: Universidade de Santiago de Compostela

Ano de defensa: 2022

Departamento:
  1. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica

Tipo: Tese

Resumo

In the present thesis, the research, development, and characterization processes of controlled drug delivery systems intended for the treatment of two different ocular pathologies were described. Firstly, different types of lactoferrin-loaded nanoparticles intended for topical ophthalmic administration were developed and proposed as the first pharmacological alternative for the Keratoconus (KC) treatment. On the other hand, idebenone-loaded polymeric implants and microparticles were designed and proposed as new therapeutic strategies for the treatment of Leber's Hereditary Optic Neuropathy (LHON).