Research and development of advanced controlled drug delivery systemsapplication in Keratoconus and Leber´s Hereditary Optic Neuropathy

  1. Varela Fernández, Rubén
Dirigida por:
  1. Francisco Javier Otero Espinar Director
  2. Isabel Lema Gesto Directora
  3. Miguel González Barcia Director/a

Universidad de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 27 de junio de 2022

Tribunal:
  1. José Blanco Méndez Presidente
  2. Arantxa Acera Osa Secretario/a
  3. Alicia C. López Castellano Vocal
Departamento:
  1. Departamento de Farmacología, Farmacia y Tecnología Farmacéutica

Tipo: Tesis

Teseo: 733876 DIALNET lock_openMINERVA editor

Resumen

In the present thesis, the research, development, and characterization processes of controlled drug delivery systems intended for the treatment of two different ocular pathologies were described. Firstly, different types of lactoferrin-loaded nanoparticles intended for topical ophthalmic administration were developed and proposed as the first pharmacological alternative for the Keratoconus (KC) treatment. On the other hand, idebenone-loaded polymeric implants and microparticles were designed and proposed as new therapeutic strategies for the treatment of Leber's Hereditary Optic Neuropathy (LHON).