Research and development of advanced controlled drug delivery systemsapplication in Keratoconus and Leber´s Hereditary Optic Neuropathy

  1. Varela Fernández, Rubén
unter der Leitung von:
  1. Francisco Javier Otero Espinar Doktorvater
  2. Isabel Lema Gesto Doktormutter
  3. Miguel González Barcia Doktorvater/Doktormutter

Universität der Verteidigung: Universidade de Santiago de Compostela

Fecha de defensa: 27 von Juni von 2022

Gericht:
  1. José Blanco Méndez Präsident
  2. Maria Aranzazu Acera Osa Sekretär/in
  3. Alicia C. López Castellano Vocal
Fachbereiche:
  1. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica

Art: Dissertation

Teseo: 733876 DIALNET lock_openMINERVA editor

Zusammenfassung

In the present thesis, the research, development, and characterization processes of controlled drug delivery systems intended for the treatment of two different ocular pathologies were described. Firstly, different types of lactoferrin-loaded nanoparticles intended for topical ophthalmic administration were developed and proposed as the first pharmacological alternative for the Keratoconus (KC) treatment. On the other hand, idebenone-loaded polymeric implants and microparticles were designed and proposed as new therapeutic strategies for the treatment of Leber's Hereditary Optic Neuropathy (LHON).