Quality-by-design approach for the development of lipid-based nanosystems for anti-mycobacterial therapy

  1. Rouco Taboada, Helena
Dirixida por:
  1. Mariana Landín Pérez Director
  2. Carmen Remuñán López Director

Universidade de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 11 de marzo de 2021

Tribunal:
  1. Ana Isabel Torres Suárez Presidente/a
  2. Carlos Alberto García González Secretario
  3. Ana Margarida Moutinho Grenha Vogal

Tipo: Tese

Resumo

In this work, we rationally developed a lipid-based nanotechnological platform for hydrophobic anti-mycobacterial drugs. For this purpose, Artificial Intelligence tools were employed to assist formulation development, from the initial design to its conversion into a solid dosage form. Reproducible nanocarriers exhibiting suitable properties were achieved through a simple and robust procedure. Furthermore, the analysis of their in vitro performance revealed promising results in terms of permeability, cell uptake and selective intracellular release. Thus demonstrating the potential of these nanosystems to treat intestinal intracellular infections, increasingly related with Crohn´s disease development.