Quality-by-design approach for the development of lipid-based nanosystems for anti-mycobacterial therapy

  1. Helena Rouco Taboada
Supervised by:
  1. Mariana Landín Pérez Director
  2. Carmen Remuñán López Director

Defence university: Universidade de Santiago de Compostela

Year of defence: 2021

  1. Ana Isabel Torres Suárez Chair
  2. Carlos Alberto García González Secretary
  3. Ana Margarida Moutinho Grenha Committee member
  1. Department of Pharmacology, Pharmacy and Pharmaceutical Technology

Type: Thesis


In this work, we rationally developed a lipid-based nanotechnological platform for hydrophobic anti-mycobacterial drugs. For this purpose, Artificial Intelligence tools were employed to assist formulation development, from the initial design to its conversion into a solid dosage form. Reproducible nanocarriers exhibiting suitable properties were achieved through a simple and robust procedure. Furthermore, the analysis of their in vitro performance revealed promising results in terms of permeability, cell uptake and selective intracellular release. Thus demonstrating the potential of these nanosystems to treat intestinal intracellular infections, increasingly related with Crohn´s disease development.