Quality-by-design approach for the development of lipid-based nanosystems for anti-mycobacterial therapy

  1. Helena Rouco Taboada
unter der Leitung von:
  1. Mariana Landín Pérez Doktormutter
  2. Carmen Remuñán López Doktormutter

Universität der Verteidigung: Universidade de Santiago de Compostela

Jahr der Verteidigung: 2021

  1. Ana Isabel Torres Suárez Präsident/in
  2. Carlos Alberto García González Sekretär
  3. Ana Margarida Moutinho Grenha Vocal
  1. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica

Art: Dissertation


In this work, we rationally developed a lipid-based nanotechnological platform for hydrophobic anti-mycobacterial drugs. For this purpose, Artificial Intelligence tools were employed to assist formulation development, from the initial design to its conversion into a solid dosage form. Reproducible nanocarriers exhibiting suitable properties were achieved through a simple and robust procedure. Furthermore, the analysis of their in vitro performance revealed promising results in terms of permeability, cell uptake and selective intracellular release. Thus demonstrating the potential of these nanosystems to treat intestinal intracellular infections, increasingly related with Crohn´s disease development.