Nanocápsulas de poliaminoácidos para la liberación selectiva de fármacos antitumorales

  1. LOLLO, GIOVANNA
Supervised by:
  1. María José Alonso Fernández Director
  2. Marcos García Fuentes Co-director
  3. Dolores Torres López Co-director

Defence university: Universidade de Santiago de Compostela

Fecha de defensa: 09 July 2012

Committee:
  1. María J. Vicent Docon Chair
  2. María de la Fuente Freire Secretary
  3. F. Quaglia Committee member
  4. Catherine Passirani Committee member
  5. Pilar Calvo Salde Committee member
Department:
  1. Department of Pharmacology, Pharmacy and Pharmaceutical Technology

Type: Thesis

Teseo: 342539 DIALNET lock_openMINERVA editor

Abstract

The main objective of this thesis has been design and the evaluation of polyyaminoacid nanocapsules for the delivery of the anticancer compouds. These systems, composed of an oil core and a shell made of polyglutamic acid (PGA) or PGA-PEG, emerge as new pltforms for the targeting of antitumor hydrophobic drugs suschas plitidepsein ann docetaxel. We have investigated the influence of the PEGylation dregee on the circulation time and distribution pattern of the nanosystems after IV administration.