Departamento de Química Orgánica
Departamento
![Foto de Alejandro](/img/nophoto.png)
Alejandro
Beceiro Casas
Publicaciones en las que colabora con Alejandro Beceiro Casas (17)
2024
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Novel Penicillin-Based Sulfone-Siderophore Conjugates for Restoring β-Lactam Antibiotic Efficacy
ACS Omega, Vol. 9, Núm. 24, pp. 26484-26494
2023
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Antimicrobial Activity of Cefiderocol against the Carbapenemase-Producing Enterobacter cloacae Complex and Characterization of Reduced Susceptibility Associated with Metallo-β-Lactamase VIM-1
Antimicrobial agents and chemotherapy, Vol. 67, Núm. 5, pp. e0150522
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In vitro development of imipenem/relebactam resistance in KPC-producing Klebsiella pneumoniae involves multiple mutations including OmpK36 disruption and KPC modification
International Journal of Antimicrobial Agents, Vol. 62, Núm. 4
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Interplay between OXA-10 β-Lactamase Production and Low Outer-Membrane Permeability in Carbapenem Resistance in Enterobacterales
Antibiotics, Vol. 12, Núm. 6
2022
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Selection of AmpC β-Lactamase Variants and Metalloβ- Lactamases Leading to Ceftolozane/Tazobactam and Ceftazidime/Avibactam Resistance during Treatment of MDR/ XDR Pseudomonas aeruginosa Infections
Antimicrobial Agents and Chemotherapy, Vol. 66, Núm. 2
2021
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6-Halopyridylmethylidene Penicillin-Based Sulfones Efficiently Inactivate the Natural Resistance of Pseudomonas aeruginosa to β-Lactam Antibiotics
Journal of Medicinal Chemistry, Vol. 64, Núm. 9, pp. 6310-6328
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Activity of imipenem, meropenem, cefepime, and sulbactam in combination with the β-lactamase inhibitor ln-1-255 against acinetobacter spp.
Antibiotics, Vol. 10, Núm. 2, pp. 1-15
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Molecular mechanisms driving the in vivo development of OXA-10-mediated resistance to ceftolozane/tazobactam and ceftazidime/avibactam during treatment of XDR Pseudomonas aeruginosa infections
The Journal of antimicrobial chemotherapy, Vol. 76, Núm. 1, pp. 91-100
2020
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6-Arylmethylidene Penicillin-Based Sulfone Inhibitors for Repurposing Antibiotic Efficiency in Priority Pathogens
Journal of Medicinal Chemistry, Vol. 63, Núm. 7, pp. 3737-3755
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Molecular and biochemical insights into the in vivo evolution of AmpC-mediated resistance to ceftolozane/tazobactam during treatment of an MDR Pseudomonas aeruginosa infection
The Journal of antimicrobial chemotherapy, Vol. 75, Núm. 11, pp. 3209-3217
2019
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Challenging antimicrobial susceptibility and evolution of resistance (oxa-681) during treatment of a long-term nosocomial infection caused by a pseudomonas aeruginosa ST175 Clone
Antimicrobial Agents and Chemotherapy, Vol. 63, Núm. 10
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Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii
Antimicrobial Agents and Chemotherapy, Vol. 63, Núm. 10
2017
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Activity of the ß-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D ß-Lactamases from acinetobacter baumannii
Antimicrobial Agents and Chemotherapy, Vol. 61, Núm. 11
2016
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LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48
Journal of Antimicrobial Chemotherapy, Vol. 71, Núm. 8, pp. 2171-2180
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Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy
Chemistry - A European Journal, Vol. 22, Núm. 8, pp. 2758-2768
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Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme
Journal of Medicinal Chemistry, Vol. 59, Núm. 11, pp. 5471-5487
2015
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Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct
Journal of the American Chemical Society, Vol. 137, Núm. 29, pp. 9333-9343