Publications by the researcher in collaboration with Alejandro Beceiro Casas (18)

2024

  1. Impact of transferable β-lactamases and intrinsic AmpC amino acid substitutions on the activity of cefiderocol against wild-type and iron uptake-deficient mutants of Pseudomonas aeruginosa

    The Journal of antimicrobial chemotherapy, Vol. 79, Núm. 11, pp. 3023-3028

  2. Novel Penicillin-Based Sulfone-Siderophore Conjugates for Restoring β-Lactam Antibiotic Efficacy

    ACS Omega, Vol. 9, Núm. 24, pp. 26484-26494

2023

  1. Antimicrobial Activity of Cefiderocol against the Carbapenemase-Producing Enterobacter cloacae Complex and Characterization of Reduced Susceptibility Associated with Metallo-β-Lactamase VIM-1

    Antimicrobial agents and chemotherapy, Vol. 67, Núm. 5, pp. e0150522

  2. In vitro development of imipenem/relebactam resistance in KPC-producing Klebsiella pneumoniae involves multiple mutations including OmpK36 disruption and KPC modification

    International Journal of Antimicrobial Agents, Vol. 62, Núm. 4

  3. Interplay between OXA-10 β-Lactamase Production and Low Outer-Membrane Permeability in Carbapenem Resistance in Enterobacterales

    Antibiotics, Vol. 12, Núm. 6

2022

  1. Selection of AmpC β-Lactamase Variants and Metalloβ- Lactamases Leading to Ceftolozane/Tazobactam and Ceftazidime/Avibactam Resistance during Treatment of MDR/ XDR Pseudomonas aeruginosa Infections

    Antimicrobial Agents and Chemotherapy, Vol. 66, Núm. 2

2021

  1. 6-Halopyridylmethylidene Penicillin-Based Sulfones Efficiently Inactivate the Natural Resistance of Pseudomonas aeruginosa to β-Lactam Antibiotics

    Journal of Medicinal Chemistry, Vol. 64, Núm. 9, pp. 6310-6328

  2. Activity of imipenem, meropenem, cefepime, and sulbactam in combination with the β-lactamase inhibitor ln-1-255 against acinetobacter spp.

    Antibiotics, Vol. 10, Núm. 2, pp. 1-15

  3. Molecular mechanisms driving the in vivo development of OXA-10-mediated resistance to ceftolozane/tazobactam and ceftazidime/avibactam during treatment of XDR Pseudomonas aeruginosa infections

    The Journal of antimicrobial chemotherapy, Vol. 76, Núm. 1, pp. 91-100

2020

  1. 6-Arylmethylidene Penicillin-Based Sulfone Inhibitors for Repurposing Antibiotic Efficiency in Priority Pathogens

    Journal of Medicinal Chemistry, Vol. 63, Núm. 7, pp. 3737-3755

  2. Molecular and biochemical insights into the in vivo evolution of AmpC-mediated resistance to ceftolozane/tazobactam during treatment of an MDR Pseudomonas aeruginosa infection

    The Journal of antimicrobial chemotherapy, Vol. 75, Núm. 11, pp. 3209-3217

2019

  1. Challenging antimicrobial susceptibility and evolution of resistance (oxa-681) during treatment of a long-term nosocomial infection caused by a pseudomonas aeruginosa ST175 Clone

    Antimicrobial Agents and Chemotherapy, Vol. 63, Núm. 10

  2. Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii

    Antimicrobial Agents and Chemotherapy, Vol. 63, Núm. 10

2017

  1. Activity of the ß-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D ß-Lactamases from acinetobacter baumannii

    Antimicrobial Agents and Chemotherapy, Vol. 61, Núm. 11

2016

  1. LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48

    Journal of Antimicrobial Chemotherapy, Vol. 71, Núm. 8, pp. 2171-2180

  2. Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy

    Chemistry - A European Journal, Vol. 22, Núm. 8, pp. 2758-2768

  3. Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme

    Journal of Medicinal Chemistry, Vol. 59, Núm. 11, pp. 5471-5487

2015

  1. Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct

    Journal of the American Chemical Society, Vol. 137, Núm. 29, pp. 9333-9343