María Isabel
Loza García
Catedrática de universidad
MARIA DE LOS ANGELES
CASTRO PEREZ
Profesora titular de universidad
Publicaciones en las que colabora con MARIA DE LOS ANGELES CASTRO PEREZ (23)
2023
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Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents – Design, synthesis, structural studies and pharmacological profiling
European Journal of Medicinal Chemistry, Vol. 252
2022
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An Experience of Using a Canvas-Based Template for Blended-Learning in a Master in Drug Discovery
International Journal of Emerging Technologies in Learning, Vol. 17, Núm. 6, pp. 257-267
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Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety
ChemMedChem, Vol. 17, Núm. 15
2021
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Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder
ACS Chemical Neuroscience, Vol. 12, Núm. 8, pp. 1313-1327
2020
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1-(2′-Bromobenzyl)-6,7-dihydroxy- N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D2 Dopamine Receptors
Journal of Natural Products, Vol. 83, Núm. 1, pp. 127-133
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Essential role of the C148–C227 disulphide bridge in the human 5-HT2A homodimeric receptor
Biochemical Pharmacology, Vol. 177
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New serotoninergic ligands containing indolic and methyl indolic nuclei: Synthesis and in vitro pharmacological evaluation
Medicinal Chemistry, Vol. 16, Núm. 4, pp. 517-530
2019
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2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenosine receptor antagonists: Synthesis and structure-activity relationships
Bioorganic and Medicinal Chemistry, Vol. 27, Núm. 16, pp. 3551-3558
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Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs
European Journal of Medicinal Chemistry, Vol. 180, pp. 673-689
2017
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Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors
Scientific Reports, Vol. 7, Núm. 1
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Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization
European Journal of Pharmacology, Vol. 815, pp. 138-146
2016
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Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation
European Journal of Medicinal Chemistry, Vol. 112, pp. 258-269
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Structure-Based Virtual Screening for Dopamine D2 Receptor Ligands as Potential Antipsychotics
ChemMedChem, Vol. 11, Núm. 7, pp. 718-729
2014
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Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles
European Journal of Medicinal Chemistry, Vol. 77, pp. 91-95
2013
2012
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New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure-activity relationships
European Journal of Medicinal Chemistry, Vol. 54, pp. 303-310
2011
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Synthesis of novel chromene scaffolds for adenosine receptors
Organic and Biomolecular Chemistry, Vol. 9, Núm. 11, pp. 4242-4249
2010
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Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13
Biochemical Journal, Vol. 432, Núm. 3, pp. 451-459
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Phe369(7.38) at human 5-HT 7 receptors confers interspecies selectivity to antagonists and partial agonists
British Journal of Pharmacology, Vol. 159, Núm. 5, pp. 1069-1081
2009
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Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine2A receptor homodimers
Molecular Pharmacology, Vol. 75, Núm. 6, pp. 1380-1391