Publicacións (149) Publicacións de XERARDO XUSTO GARCIA MERA

2024

  1. Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity

    RSC Medicinal Chemistry

  2. Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents

    Biomedicine and Pharmacotherapy, Vol. 173

  3. Exploring structural determinants of neuroprotection bias on novel glypromate conjugates with bioactive amines

    European Journal of Medicinal Chemistry, Vol. 267

2023

  1. Concise Overview of Glypromate Neuropeptide Research: From Chemistry to Pharmacological Applications in Neurosciences

    ACS Chemical Neuroscience, Vol. 14, Núm. 4, pp. 554-572

  2. Exploring the Effect of Halogenation in a Series of Potent and Selective A2BAdenosine Receptor Antagonists

    Journal of Medicinal Chemistry, Vol. 66, Núm. 1, pp. 890-912

  3. Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs

    Biomedicine and Pharmacotherapy, Vol. 164

  4. Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors

    ACS Medicinal Chemistry Letters, Vol. 14, Núm. 12, pp. 1656-1663

2022

  1. A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models

    Journal for ImmunoTherapy of Cancer, Vol. 10, Núm. 5

  2. Exploring Non-orthosteric Interactions with a Series of Potent and Selective A3Antagonists

    ACS Medicinal Chemistry Letters, Vol. 13, Núm. 2, pp. 243-249

  3. Isolation and structural characterization of stable carbamic-carbonic anhydrides: an experimental and computational study

    Organic Chemistry Frontiers, Vol. 9, Núm. 8, pp. 2154-2163

  4. Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1Antagonists

    Journal of Medicinal Chemistry, Vol. 65, Núm. 3, pp. 2091-2106

2021

  1. 3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition

    Journal of medicinal chemistry, Vol. 64, Núm. 1, pp. 458-480

  2. Catalytic performance of a metal-free graphene oxide-Al2O3 composite assembled by 3D printing

    Journal of the European Ceramic Society, Vol. 41, Núm. 2, pp. 1399-1406

  3. Design, Synthesis, and Biological Evaluation of Hybrid Glypromate Analogues Using 2-Azanorbornane as a Prolyl and Pipecolyl Surrogate

    ACS Chemical Neuroscience, Vol. 12, Núm. 19, pp. 3615-3624

  4. Discovery of New Potent Positive Allosteric Modulators of Dopamine D2Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide

    Journal of Medicinal Chemistry, Vol. 64, Núm. 9, pp. 6209-6220

  5. Potent and Subtype-Selective Dopamine D2Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach

    Journal of Medicinal Chemistry, Vol. 64, Núm. 12, pp. 8710-8726

2020

  1. A sustainable strategy for the assembly of Glypromate® and its structurally-related analogues by tandem sequential peptide coupling

    Green Chemistry, Vol. 22, Núm. 11, pp. 3584-3596

  2. Bioinspired design for the assembly of Glypromate® neuropeptide conjugates with active pharmaceutical ingredients

    New Journal of Chemistry, Vol. 44, Núm. 48, pp. 21049-21063

  3. Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists

    Journal of medicinal chemistry, Vol. 63, Núm. 14, pp. 7721-7739

  4. X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A2A Adenosine Receptor Antagonists

    Angewandte Chemie - International Edition, Vol. 59, Núm. 38, pp. 16536-16543