Publicacións nas que colabora con José Manuel Brea Floriani (19)

2024

  1. 2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives

    Molecules, Vol. 29, Núm. 11

2022

  1. An Experience of Using a Canvas-Based Template for Blended-Learning in a Master in Drug Discovery

    International Journal of Emerging Technologies in Learning, Vol. 17, Núm. 6, pp. 257-267

2020

  1. Essential role of the C148–C227 disulphide bridge in the human 5-HT2A homodimeric receptor

    Biochemical Pharmacology, Vol. 177

  2. New serotoninergic ligands containing indolic and methyl indolic nuclei: Synthesis and in vitro pharmacological evaluation

    Medicinal Chemistry, Vol. 16, Núm. 4, pp. 517-530

2019

  1. 2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenosine receptor antagonists: Synthesis and structure-activity relationships

    Bioorganic and Medicinal Chemistry, Vol. 27, Núm. 16, pp. 3551-3558

2017

  1. Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors

    Scientific Reports, Vol. 7, Núm. 1

  2. Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization

    European Journal of Pharmacology, Vol. 815, pp. 138-146

2016

  1. 8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease

    ChemistrySelect, Vol. 1, Núm. 11, pp. 2742-2749

2015

  1. Computer-aided structure-based design of multitarget leads for Alzheimer's disease

    Journal of Chemical Information and Modeling, Vol. 55, Núm. 1, pp. 135-148

2014

  1. Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles

    European Journal of Medicinal Chemistry, Vol. 77, pp. 91-95

2013

  1. The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling

    Pharmacology Research and Perspectives, Vol. 1, Núm. 2

2012

  1. New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure-activity relationships

    European Journal of Medicinal Chemistry, Vol. 54, pp. 303-310

2011

  1. Synthesis of novel chromene scaffolds for adenosine receptors

    Organic and Biomolecular Chemistry, Vol. 9, Núm. 11, pp. 4242-4249

2010

  1. Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13

    Biochemical Journal, Vol. 432, Núm. 3, pp. 451-459

  2. Phe369(7.38) at human 5-HT 7 receptors confers interspecies selectivity to antagonists and partial agonists

    British Journal of Pharmacology, Vol. 159, Núm. 5, pp. 1069-1081

2009

  1. Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine2A receptor homodimers

    Molecular Pharmacology, Vol. 75, Núm. 6, pp. 1380-1391

2008

  1. A new chemical tool (C0036E08) supports the role of adenosine A2B receptors in mediating human mast cell activation

    Biochemical Pharmacology, Vol. 76, Núm. 7, pp. 912-921

2006

  1. Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells

    Neuropharmacology, Vol. 51, Núm. 4, pp. 923-932

  2. QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine

    Neuropharmacology, Vol. 51, Núm. 2, pp. 251-262