Publications by the researcher in collaboration with María Isabel Loza García (23)

2023

  1. Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents – Design, synthesis, structural studies and pharmacological profiling

    European Journal of Medicinal Chemistry, Vol. 252

2022

  1. An Experience of Using a Canvas-Based Template for Blended-Learning in a Master in Drug Discovery

    International Journal of Emerging Technologies in Learning, Vol. 17, Núm. 6, pp. 257-267

  2. Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety

    ChemMedChem, Vol. 17, Núm. 15

2021

  1. Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder

    ACS Chemical Neuroscience, Vol. 12, Núm. 8, pp. 1313-1327

2020

  1. 1-(2′-Bromobenzyl)-6,7-dihydroxy- N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D2 Dopamine Receptors

    Journal of Natural Products, Vol. 83, Núm. 1, pp. 127-133

  2. Essential role of the C148–C227 disulphide bridge in the human 5-HT2A homodimeric receptor

    Biochemical Pharmacology, Vol. 177

  3. New serotoninergic ligands containing indolic and methyl indolic nuclei: Synthesis and in vitro pharmacological evaluation

    Medicinal Chemistry, Vol. 16, Núm. 4, pp. 517-530

2019

  1. 2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenosine receptor antagonists: Synthesis and structure-activity relationships

    Bioorganic and Medicinal Chemistry, Vol. 27, Núm. 16, pp. 3551-3558

  2. Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs

    European Journal of Medicinal Chemistry, Vol. 180, pp. 673-689

2017

  1. Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors

    Scientific Reports, Vol. 7, Núm. 1

  2. Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization

    European Journal of Pharmacology, Vol. 815, pp. 138-146

2016

  1. Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation

    European Journal of Medicinal Chemistry, Vol. 112, pp. 258-269

  2. Structure-Based Virtual Screening for Dopamine D2 Receptor Ligands as Potential Antipsychotics

    ChemMedChem, Vol. 11, Núm. 7, pp. 718-729

2014

  1. Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles

    European Journal of Medicinal Chemistry, Vol. 77, pp. 91-95

2013

  1. The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling

    Pharmacology Research and Perspectives, Vol. 1, Núm. 2

2012

  1. New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure-activity relationships

    European Journal of Medicinal Chemistry, Vol. 54, pp. 303-310

2011

  1. Synthesis of novel chromene scaffolds for adenosine receptors

    Organic and Biomolecular Chemistry, Vol. 9, Núm. 11, pp. 4242-4249

2010

  1. Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13

    Biochemical Journal, Vol. 432, Núm. 3, pp. 451-459

  2. Phe369(7.38) at human 5-HT 7 receptors confers interspecies selectivity to antagonists and partial agonists

    British Journal of Pharmacology, Vol. 159, Núm. 5, pp. 1069-1081

2009

  1. Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine2A receptor homodimers

    Molecular Pharmacology, Vol. 75, Núm. 6, pp. 1380-1391