Descubrimento e síntese de fármacos
Desinfarma
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Universidade Do Porto
Oporto, PortugalPublicacións en colaboración con investigadores/as de Universidade Do Porto (56)
2024
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Exploring structural determinants of neuroprotection bias on novel glypromate conjugates with bioactive amines
European Journal of Medicinal Chemistry, Vol. 267
2023
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Concise Overview of Glypromate Neuropeptide Research: From Chemistry to Pharmacological Applications in Neurosciences
ACS Chemical Neuroscience, Vol. 14, Núm. 4, pp. 554-572
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Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors
ACS Medicinal Chemistry Letters, Vol. 14, Núm. 12, pp. 1656-1663
2022
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Isolation and structural characterization of stable carbamic-carbonic anhydrides: an experimental and computational study
Organic Chemistry Frontiers, Vol. 9, Núm. 8, pp. 2154-2163
2021
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Design, Synthesis, and Biological Evaluation of Hybrid Glypromate Analogues Using 2-Azanorbornane as a Prolyl and Pipecolyl Surrogate
ACS Chemical Neuroscience, Vol. 12, Núm. 19, pp. 3615-3624
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Discovery of New Potent Positive Allosteric Modulators of Dopamine D2Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide
Journal of Medicinal Chemistry, Vol. 64, Núm. 9, pp. 6209-6220
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Synthesis, Pharmacological, and Biological Evaluation of 2-Furoyl-Based MIF-1 Peptidomimetics and the Development of a General-Purpose Model for Allosteric Modulators (ALLOPTML)
ACS Chemical Neuroscience, Vol. 12, Núm. 1, pp. 203-215
2020
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A sustainable strategy for the assembly of Glypromate® and its structurally-related analogues by tandem sequential peptide coupling
Green Chemistry, Vol. 22, Núm. 11, pp. 3584-3596
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Bioinspired design for the assembly of Glypromate® neuropeptide conjugates with active pharmaceutical ingredients
New Journal of Chemistry, Vol. 44, Núm. 48, pp. 21049-21063
2019
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Mechanistic insights for the transprotection of tertiary amines with Boc2O: Via charged carbamates: Access to both enantiomers of 2-azanorbornane-3- exo -carboxylic acids
Organic Chemistry Frontiers, Vol. 6, Núm. 20, pp. 3540-3554
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Synthesis, Pharmacological, and Biological Evaluation of MIF-1 Picolinoyl Peptidomimetics as Positive Allosteric Modulators of D2R
ACS Chemical Neuroscience, Vol. 10, Núm. 8, pp. 3690-3702
2017
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Highly efficient one-pot assembly of peptides by double chemoselective coupling
Organic and Biomolecular Chemistry, Vol. 15, Núm. 36, pp. 7533-7542
2016
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Novel l-prolyl-l-leucylglycinamide (PLG) tripeptidomimetics based on a 2-azanorbornane scaffold as positive allosteric modulators of the D2R
Organic and Biomolecular Chemistry, Vol. 14, Núm. 47, pp. 11065-11069
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On the scope of oxidation of tertiary amines: Meisenheimer rearrangements: Versus Cope elimination in 2-(cyanoethyl)-2-azanorbornanes
Organic Chemistry Frontiers, Vol. 3, Núm. 12, pp. 1624-1634
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Synthesis and characterization of 1-pyrindane derivatives as rasagiline analogues
Chemical Data Collections
2015
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Enantiopure synthesis of 7-(1-pyrindanyl)propargyl ethers as rasagiline analogues via chemical or enzymatic resolution of 1-pyrindan-7-ol
RSC Advances, Vol. 5, Núm. 126, pp. 104509-104515
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Reactivity and Mechanistic Studies of the Reactions of Chlorodiphenylphosphine and Its Oxide with Methyl Glyoxylate, Glyoxylate Oximes, and Methyl Cyanoformate
Heteroatom Chemistry, Vol. 26, Núm. 4, pp. 249-256
2014
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Endo-benzonorbornen-2-ol as an efficient non-natural chiral auxiliary in the asymmetric aza-Diels-Alder reactions between cyclopentadiene and (1-phenylethyl)iminoacetates
RSC Advances, Vol. 4, Núm. 101, pp. 57768-57772
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Synthesis and N-functionalization of isoxazolidines: A new approach to nucleoside analogues
Tetrahedron Letters, Vol. 55, Núm. 33, pp. 4628-4631
2013
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Highly stereoselective cycloadditions of Danishefsky's diene to (-)-8-phenylmenthyl and (+)-8-phenylneomenthyl glyoxylate N-phenylethylimines
Tetrahedron, Vol. 69, Núm. 14, pp. 2909-2919