Publicacións en colaboración con investigadores/as de Universidade Do Porto (57)

2024

  1. Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity

    RSC Medicinal Chemistry

  2. Exploring structural determinants of neuroprotection bias on novel glypromate conjugates with bioactive amines

    European Journal of Medicinal Chemistry, Vol. 267

2023

  1. Concise Overview of Glypromate Neuropeptide Research: From Chemistry to Pharmacological Applications in Neurosciences

    ACS Chemical Neuroscience, Vol. 14, Núm. 4, pp. 554-572

  2. Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors

    ACS Medicinal Chemistry Letters, Vol. 14, Núm. 12, pp. 1656-1663

2022

  1. Isolation and structural characterization of stable carbamic-carbonic anhydrides: an experimental and computational study

    Organic Chemistry Frontiers, Vol. 9, Núm. 8, pp. 2154-2163

2021

  1. Design, Synthesis, and Biological Evaluation of Hybrid Glypromate Analogues Using 2-Azanorbornane as a Prolyl and Pipecolyl Surrogate

    ACS Chemical Neuroscience, Vol. 12, Núm. 19, pp. 3615-3624

  2. Discovery of New Potent Positive Allosteric Modulators of Dopamine D2Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide

    Journal of Medicinal Chemistry, Vol. 64, Núm. 9, pp. 6209-6220

  3. Synthesis, Pharmacological, and Biological Evaluation of 2-Furoyl-Based MIF-1 Peptidomimetics and the Development of a General-Purpose Model for Allosteric Modulators (ALLOPTML)

    ACS Chemical Neuroscience, Vol. 12, Núm. 1, pp. 203-215

2020

  1. A sustainable strategy for the assembly of Glypromate® and its structurally-related analogues by tandem sequential peptide coupling

    Green Chemistry, Vol. 22, Núm. 11, pp. 3584-3596

  2. Bioinspired design for the assembly of Glypromate® neuropeptide conjugates with active pharmaceutical ingredients

    New Journal of Chemistry, Vol. 44, Núm. 48, pp. 21049-21063

2019

  1. Mechanistic insights for the transprotection of tertiary amines with Boc2O: Via charged carbamates: Access to both enantiomers of 2-azanorbornane-3- exo -carboxylic acids

    Organic Chemistry Frontiers, Vol. 6, Núm. 20, pp. 3540-3554

  2. Synthesis, Pharmacological, and Biological Evaluation of MIF-1 Picolinoyl Peptidomimetics as Positive Allosteric Modulators of D2R

    ACS Chemical Neuroscience, Vol. 10, Núm. 8, pp. 3690-3702

2017

  1. Highly efficient one-pot assembly of peptides by double chemoselective coupling

    Organic and Biomolecular Chemistry, Vol. 15, Núm. 36, pp. 7533-7542

2016

  1. Novel l-prolyl-l-leucylglycinamide (PLG) tripeptidomimetics based on a 2-azanorbornane scaffold as positive allosteric modulators of the D2R

    Organic and Biomolecular Chemistry, Vol. 14, Núm. 47, pp. 11065-11069

  2. On the scope of oxidation of tertiary amines: Meisenheimer rearrangements: Versus Cope elimination in 2-(cyanoethyl)-2-azanorbornanes

    Organic Chemistry Frontiers, Vol. 3, Núm. 12, pp. 1624-1634

  3. Synthesis and characterization of 1-pyrindane derivatives as rasagiline analogues

    Chemical Data Collections

2015

  1. Enantiopure synthesis of 7-(1-pyrindanyl)propargyl ethers as rasagiline analogues via chemical or enzymatic resolution of 1-pyrindan-7-ol

    RSC Advances, Vol. 5, Núm. 126, pp. 104509-104515

  2. Reactivity and Mechanistic Studies of the Reactions of Chlorodiphenylphosphine and Its Oxide with Methyl Glyoxylate, Glyoxylate Oximes, and Methyl Cyanoformate

    Heteroatom Chemistry, Vol. 26, Núm. 4, pp. 249-256

2014

  1. Endo-benzonorbornen-2-ol as an efficient non-natural chiral auxiliary in the asymmetric aza-Diels-Alder reactions between cyclopentadiene and (1-phenylethyl)iminoacetates

    RSC Advances, Vol. 4, Núm. 101, pp. 57768-57772

  2. Synthesis and N-functionalization of isoxazolidines: A new approach to nucleoside analogues

    Tetrahedron Letters, Vol. 55, Núm. 33, pp. 4628-4631