Biophysical Chemistry, Photophysics and Spectroscopy

Date of inception 01 January 1999

Leader: Mercedes Novo Rodríguez

Department: Department of Physical Chemistry

Website: http://www.usc.es/fotofqm/

The BioPhysChem research group applies advanced spectroscopic techniques and single-molecule methods, particularly fluorescence correlation spectroscopy (FCS) and fluorescence microscopy, to address critical challenges in biomedicine and biotechnology. Our expertise in supramolecular association dynamics and advanced spectroscopic data analysis enables us to bridge fundamental molecular photophysics with practical applications in medical diagnostics, veterinary medicine, and therapeutic development.


We investigate peptide aggregation mechanisms, beta-amyloid oligomerization and its interaction with plasma proteins, and lipid nanoparticle systems for CRISPR/Cas9 genetic editing delivery. Through interdisciplinary collaborations with veterinary scientists, biochemists, and robotics engineers, our work focuses on developing point-of-care diagnostic devices for SARS-CoV-2, subclinical hypocalcemia in cattle farms, and biomarkers for Alzheimer's disease diagnosis. We integrate artificial intelligence-driven image analysis with zebrafish animal models and single-molecule techniques to translate photophysical principles into innovative diagnostic and therapeutic solutions.

Researchers

Former members (6)