Estudio de aplicación de la espectroscopia infrarroja al análisis cualitativo de fármacos de carácter ácido y neutro en plasma

  1. Cepeda, A. 1
  2. Paseiro, P. 1
  3. Simal, J. 1
  1. 1 Universidade de Santiago de Compostela
    info

    Universidade de Santiago de Compostela

    Santiago de Compostela, España

    ROR https://ror.org/030eybx10

Journal:
Revista de toxicología

ISSN: 0212-7113

Year of publication: 1987

Volume: 4

Issue: 1

Pages: 19-29

Type: Article

DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Revista de toxicología

Abstract

We describe a method to identify Barbiturates, Salicylic Acid, Paracetamol, Caffeine and Theophylline at their toxic levels in plasma based on the purification of the sample with the Sep Pak C18 minicolumns and the analysis of the residue obtained by the IR spectroscopy.

Bibliographic References

  • BURKE, J. T., and THENOT, J. P.: Determination of Antiepileptic Drugs. J. Chromat. 34a 199-241, 1985.
  • DROST, R. H. et al.: EMIT-st Drugs Detection System for Screening of Barbiturates and Benzodiazepines. J. Toxicol. Clin. 19 (3): 303-312, 1982.
  • EHRESMAN, D. J., ef al.: Screening Biological Samples for Underivatized using a Splitless Injection Technique of Fused-Silica Capillary Column GC. J. Anal. Toxicol. 9: 55-62, 1985.
  • FRATI, M. E.;MARRUECOS, M.; PORTA, M.;MARTIN, M. L, and LAPORTE, J. R.: Acute SeverePoisoning in Spain: Clinical Outcome Related to the Implicated Drugs. Human Toxicology 2: 625-632, 1983.
  • GILL, R., ef al.: ACollaborative Study to Investígate the Retention Reproductibility of Barbiturates in HPLC whith a View to Establishing Retention Data Bases for Drugs Identification. J. Chromat. Sci. 24: 153-159, 1986.
  • GUPTA, R. N.:Drugs Vol. 1 en Handbook of Chromatography. Zweig, G. And Sherma, J. (Eds.). Florida. E. CRC Press, 1981.
  • GUPTA, R. N.: Drug Level Monotoring Sedative Hypnotics. J. Chromat. 340: 139-172, 1985.
  • JAIN, N. C, and CRAVEY, R. H.: TheIdentification of Barbiturates from Biological Specimens. J. Chromat. Sci. 12: 228-231, 1974.
  • KABRA, P. M.; STAFFORD, B. E., and MARTON, L. J.: Rapid Method for Screening Toxic Drugs in Serum with Liquid Chromatography. J. Anal. Toxicol. 5: 177-182, 1981.
  • LEVINE, R. R.:FARMACOLOGÍA: Acciones y reacciones medicamentosas. Barcelona. Ed. Salvat. 321, 1982.
  • MARQUES, J. M., et al.: Barbitúricos: Propuesta de análisis semicuantitativo en Toxicología de urgencia. V Jornadas Toxicológicas. Madrid. Ed. COFM, 1983.
  • SKOUTAKIS, J. A.: Clinical Toxicology of Drugs: Principies andPractice. Chaptern 1. Philadelphia: Ed. Lea and Febiger. 22-24, 1982.
  • STEAD, A. H., and MOFFAT, A. C: A Collection of Therapeutic, Toxicand Fatal Blood Drug Concentrations in Man. Human Toxicology 3: 437-464, 1983.
  • WAD, N. T., and ROSEMUND, H.: Rapid Quantitative Method for the Simultaneous Determination of Carbamezepine, Carbamezepine 10-11 epóxide, Diphenylhidantoin, Mephenytoin, Phenobarbital and Primidone in Serum by TLC. J. Chromat 746:361-362,1978.
  • WANG, S. T., and PETER, F.: The Abbott TDx Fluorescence Polarization Inmunoassay and LC Compared for Five Anticonvulsant Drugs in Serum. Clin. Chem 37 (3): 493-494. 1985.
Data source: Dialnet