Estudios PET con FMISO para la localización de regiones hipóxicas "in vivo" en modelos experimentales

  1. Noemí Gómez-Lado
Supervised by:
  1. Pablo Aguiar Fernández Director
  2. Alvaro Ruibal Morell Director
  3. Antonio Manuel Castro Castro Tutor

Defence university: Universidade da Coruña

Year of defence: 2022

  1. Francisco Javier Otero Espinar Chair
  2. Javier Pereira-Loureiro Secretary
  3. Aida Niñerola Baizán Committee member

Type: Thesis

Teseo: 710074 DIALNET lock_openRUC editor


Fluoromisonidazole ([18F]FMISO) is a radiopharmaceutical used for the detection of hypoxic tissues in vivo by PET. Because the accumulation of this tracer is inversely related to cellular oxygen partial pressure, it could be a potential indicator of penumbra, that is, potentially salvageable damaged tissue. The main objective of this PhD Thesis is to explore the use of FMISO in experimental models of cerebral hemorrhage and peripheral arterial disease induced in rats. This Doctoral Thesis has confirmed the feasibility of the PET technique with FMISO for the study of the presence of hypoxic regions in vivo, being a useful tool for monitoring the evolution of a particular pathology in clinical trials with patients.