Protocolo clínico de fibrina rica en plaquetas y leucocitos (L-PRF) para tratamiento de pacientes con osteonecrosis medicamentosa (ONM)a propósito de un caso

  1. C López Rodríguez 1
  2. A. Castellano 1
  3. Pilar Gándara Vila 2
  4. Mario Pérez-Sayáns 1
  1. 1 Universidade de Santiago de Compostela

    Universidade de Santiago de Compostela

    Santiago de Compostela, España


  2. 2 Universidad de Santiago de CompostelaUniversidad de Santiago de Compostela
RCOE: Revista del Ilustre Consejo General de Colegios de Odontólogos y Estomatólogos de España

ISSN: 1138-123X

Ano de publicación: 2021

Volume: 26

Número: 3

Páxinas: 85-86

Tipo: Artigo

Outras publicacións en: RCOE: Revista del Ilustre Consejo General de Colegios de Odontólogos y Estomatólogos de España


Introduction: LPRF is a combination of platelet and leukocyte-rich fibrin obtained from the patient's blood. Objective: presentation of a case of MRONJ treated using the L-PRF technique Clinical case: 78-year-old woman attends the clinic of the Master's Degree in Oral Medicine, Oral Surgery and Implantology presenting a stage III drug osteonecrosis in the anterosuperior sector associated with previous extractions. The patient presents a personal history of rheumatoid arthritis and osteoporosis previous treatment with Risendronate and Denosumab and currently with corticosteroids and vitamin D. Results: Sequestrectomy of the bone fragment (2.7 x 1.5 cm) was performed under antibiotic coverage by inserting LPRF into the surgical bed (4 plugs and 4 membranes) and first closed with non-resorbable monofilament. The L-PRF was obtained using the Choukroun et al 2001 technique using the IntraSpin system® (Intralock, Florida). A complete healing of the area was observed at the same time, without bone exposure and with no symptomatology, remain stable to this day. Conclusions: The use of L-PRF in patients may be an effective alternative in the surgical treatment of MRONJ.