Epigenetic modulation of the immune system in early childhoodfrom infectious diseases to vaccines

  1. Pischedda, Sara
Supervised by:
  1. Antonio Salas Ellacuriaga Director
  2. Federico Martinón Torres Director

Defence university: Universidade de Santiago de Compostela

Fecha de defensa: 29 July 2021

Committee:
  1. Laura Sánchez Piñón Chair
  2. U. Toscanini Secretary
  3. Francesca Brisighelli Committee member
Department:
  1. Department of Forensic Science, Pathological Anatomy, Gynaecology and Obstetrics and Paediatrics

Type: Thesis

Teseo: 675734 DIALNET lock_openMINERVA editor

Abstract

Epigenetic mechanisms regulate gene expression and transcription in a dynamic way. Many functional differences observed in the immune system of neonates and adults seem to be associated with epigenetic modifications of genes that control inflammation and immune response. One of the most studied epigenetic mechanisms is DNA methylation, considered as the major epigenetic factor influencing gene activities. Using the Infinium Illumina Methylation BeadChip platform it was possible to provide insights on the role of epigenetic mechanisms, especially DNA methylation alterations, in the different respiratory sequelae observed after RSV infection and in the variable immune response observed after PCV13 in early childhood.