Epigenetic modulation of the immune system in early childhoodfrom infectious diseases to vaccines

  1. Sara Pischedda
unter der Leitung von:
  1. Antonio Salas Ellacuriaga Doktorvater
  2. Federico Martinón Torres Doktorvater

Universität der Verteidigung: Universidade de Santiago de Compostela

Jahr der Verteidigung: 2021

  1. Laura Sánchez Piñón Präsidentin
  2. U. Toscanini Sekretär/in
  3. Francesca Brisighelli Vocal
  1. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia e Pediatría

Art: Dissertation


Epigenetic mechanisms regulate gene expression and transcription in a dynamic way. Many functional differences observed in the immune system of neonates and adults seem to be associated with epigenetic modifications of genes that control inflammation and immune response. One of the most studied epigenetic mechanisms is DNA methylation, considered as the major epigenetic factor influencing gene activities. Using the Infinium Illumina Methylation BeadChip platform it was possible to provide insights on the role of epigenetic mechanisms, especially DNA methylation alterations, in the different respiratory sequelae observed after RSV infection and in the variable immune response observed after PCV13 in early childhood.