Transition metal catalyzed annulations based on the activation of c-h bonds

Resumo

This thesis describes the reactivity of simple acyclic starting materials, such as amides and carboxylic acids tethering an alkene or alkyne moiety, with different transition metal complexes. Cyclic products are synthesized by carbon hydrogen activation strategies. An oxidative annulation is achieved when a carboxylic acid with an alkyne in its structure is summited to rhodium (III) complexes in the presence of a silver salt. Remarkably, we also reported cyclization reactions using amides tetheringwith an alkene or an alkyne, achieving excelent reactivities and developing also chiral versions.