Transition metal catalyzed annulations based on the activation of c-h bonds
- José Luis Mascareñas Cid Director
- Fernando José López García Codirector
- Moisés Gulias Costa Codirector
Universidad de defensa: Universidade de Santiago de Compostela
Fecha de defensa: 12 de julio de 2019
- Carlos Saa Rodríguez Presidente
- Beatriz Royo Cantabrana Secretario/a
- Nuria Rodriguez Garrido Vocal
Tipo: Tesis
Resumen
This thesis describes the reactivity of simple acyclic starting materials, such as amides and carboxylic acids tethering an alkene or alkyne moiety, with different transition metal complexes. Cyclic products are synthesized by carbon hydrogen activation strategies. An oxidative annulation is achieved when a carboxylic acid with an alkyne in its structure is summited to rhodium (III) complexes in the presence of a silver salt. Remarkably, we also reported cyclization reactions using amides tetheringwith an alkene or an alkyne, achieving excelent reactivities and developing also chiral versions.