Estudio clínico comparativo de la eficacia de Azitromicina frente a Amoxicilina/Ac. Clavulánico en el tratamiento de infecciones orales agudas
- Bermejo Fenoll, A.
- Herrera González, D.
- Sanz Alonso, M.
- Martínez Sahuquillo, A.
- López Cedrún, J.L.
- Gay Escoda, Cosme
- Aguirre Urizar, J.M.
- García Pola, M.J.
- Gandara Rey, J.M.
- Bagán Sebastián, José Vicente
ISSN: 1138-123X
Ano de publicación: 2001
Volume: 6
Número: 4
Páxinas: 387-394
Tipo: Artigo
Outras publicacións en: RCOE: Revista del Ilustre Consejo General de Colegios de Odontólogos y Estomatólogos de España
Resumo
lntroduction: The aim of this study was to compare the efficacy, safety and tolerance of azithromycin versus amoxicillin/clavulanate in the treatment of odontogenic acute oral infections. Patients and Method: This open, comparative, multicenter study included 208 patients suffering an odontogenic acute oral infection, randomly assigned to each group. 102 patients received azithromycin, and 106 patients were treated with amoxicillin/clavulanate. A clinical history and a physical exploration were performed, and urine and blood samples were collected. At each visit, signs and symptons of each condition were assessed. Results: The clinical outcome was similar in both therapeutic groups, with a level of complete healing or improvement above 90%. Azithromycin was better tolerated, and compliance was higher than with amoxicillin/clavulanate. Most adverse effects were gastrointestinal, although not relevant. Conclusion: Azithromycin and amoxicillin/clavulanate were equally effective in the treatment of odontogenic acute oral infections, but azithromycin dosage favoured a better compliance, and less and not important adverse effects.