The obestatin/GPR39 systemfrom satellite cell regulation to its applicability in Duchenne muscular dystrophy

  1. González Sánchez, Jessica
Supervised by:
  1. Jesús Pérez Camiña Director
  2. Felipe Casanueva Freijó Director
  3. José Luis Relova Quinteiro Director

Defence university: Universidade de Santiago de Compostela

Fecha de defensa: 04 April 2019

Committee:
  1. Amelia Aranega Jiménez Chair
  2. Rosalía Gallego Gómez Secretary
  3. Eusebio Perdiguero Santamaría Committee member
Department:
  1. Department of Psychiatry, Radiology, Public Health, Nursing and Medicine

Type: Thesis

Teseo: 587053 DIALNET lock_openMINERVA editor

Abstract

The obestatin/GPR39 system functions as a mediator of skeletal muscle determination, maintenance, and plasticity in physiological and pathological conditions. In satellite cells, the obestatin/GPR39 system acts as an autocrine factor regulating cell cycle progression and fate determination. In Duchenne muscular dystrophy, obestatin signalling addresses multiple pathways needed for phenotypic amelioration, including regulation of myofibre regeneration, activation of the slow oxidative myofibre program, regulation of proteasomal signalling, stabilization of the sarcolemma and induction of corrective autophagy. The results point to the obestatin/GPR39 system as a practical and effective target for future Duchenne muscular dystrophy therapies.