The obestatin/GPR39 systemfrom satellite cell regulation to its applicability in Duchenne muscular dystrophy

  1. González Sánchez, Jessica
unter der Leitung von:
  1. Jesús Pérez Camiña Doktorvater/Doktormutter
  2. Felipe Casanueva Freijó Doktorvater
  3. José Luis Relova Quinteiro Doktorvater

Universität der Verteidigung: Universidade de Santiago de Compostela

Fecha de defensa: 04 von April von 2019

Gericht:
  1. Amelia Aranega Jiménez Präsident/in
  2. Rosalía Gallego Gómez Sekretärin
  3. Eusebio Perdiguero Santamaría Vocal
Fachbereiche:
  1. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina

Art: Dissertation

Teseo: 587053 DIALNET lock_openMINERVA editor

Zusammenfassung

The obestatin/GPR39 system functions as a mediator of skeletal muscle determination, maintenance, and plasticity in physiological and pathological conditions. In satellite cells, the obestatin/GPR39 system acts as an autocrine factor regulating cell cycle progression and fate determination. In Duchenne muscular dystrophy, obestatin signalling addresses multiple pathways needed for phenotypic amelioration, including regulation of myofibre regeneration, activation of the slow oxidative myofibre program, regulation of proteasomal signalling, stabilization of the sarcolemma and induction of corrective autophagy. The results point to the obestatin/GPR39 system as a practical and effective target for future Duchenne muscular dystrophy therapies.