Alterations of gray and white matter morphology in obsessive compulsive disorder

  1. Oscar F. Gonçalves 1
  2. Sonia Sousa 1
  3. Sandra Carvalho 1
  4. Jorge Leite 1
  5. Ana Ganho 1
  6. Ana Fernandes-Gonçalves 2
  7. Fernando Pocinho 3
  8. Angel Carracedo 4
  9. Adriana Sampaio 1
  1. 1 Universidade do Minho
    info

    Universidade do Minho

    Braga, Portugal

    ROR https://ror.org/037wpkx04

  2. 2 Cuf Hospital
  3. 3 Universidade de Coimbra
    info

    Universidade de Coimbra

    Coímbra, Portugal

    ROR https://ror.org/04z8k9a98

  4. 4 Universidade de Santiago de Compostela
    info

    Universidade de Santiago de Compostela

    Santiago de Compostela, España

    ROR https://ror.org/030eybx10

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Revista:
Psicothema

ISSN: 0214-9915

Ano de publicación: 2017

Volume: 29

Número: 1

Páxinas: 35-42

Tipo: Artigo

DOI: 10.7334/PSICOTHEMA2016.86 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Psicothema

Resumo

Antecedentes: mientras que la etiopatogenia del trastorno obsesivo-compulsivo (TOC) sigue siendo desconocida, hay una mayor evidencia en las personas que sufren este trastorno de alteraciones estructurales que incluyen, pero no se limitan, a anormalidades en regiones cortico-estriado-tálamo-corticales (CSTC). El objetivo de este estudio fue comprobar la existencia de alteraciones estructurales tanto en la materia blanca como en la materia gris en una muestra de pacientes con TOC en comparación con un grupo de controles no clínicos (NCC), utilizándose para ello análisis morfométricos basados en “voxel” (VBM). Método: quince pacientes con TOC y quince NCC fueron estudiados mediante resonancia magnética estrutural. Resultados: se encontraron alteraciones en los pacientes en regiones frontales (aumento de la materia gris en la circunvolución frontal media) y subcorticales (aumento de la materia blanca en el pallidum). Además, también se encontraron afectadas regiones témporo-parietales con una alta correlación con la gravedad de los síntomas del TOC (disminución de la materia gris en el lóbulo parietal superior y de la materia blanca en las circunvoluciones temporales angular y superior). Conclusiones: las alteraciones encontradas pueden estar asociados con síntomas predominantes en el TOC, como dificultades en el control inhibitorio (pallidum, giro angular), función ejecutiva (circunvolución frontal media), verificaciones compulsivas (circunvolución temporal superior) y déficit visual-espacial (lóbulo parietal superior).

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Fonte de datos: Dialnet