Alterations of gray and white matter morphology in obsessive compulsive disorder

  1. Oscar F. Gonçalves 1
  2. Sonia Sousa 1
  3. Sandra Carvalho 1
  4. Jorge Leite 1
  5. Ana Ganho 1
  6. Ana Fernandes-Gonçalves 2
  7. Fernando Pocinho 3
  8. Angel Carracedo 4
  9. Adriana Sampaio 1
  1. 1 Universidade do Minho
    info

    Universidade do Minho

    Braga, Portugal

    ROR https://ror.org/037wpkx04

  2. 2 Cuf Hospital
  3. 3 Universidade de Coimbra
    info

    Universidade de Coimbra

    Coímbra, Portugal

    ROR https://ror.org/04z8k9a98

  4. 4 Universidade de Santiago de Compostela
    info

    Universidade de Santiago de Compostela

    Santiago de Compostela, España

    ROR https://ror.org/030eybx10

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Journal:
Psicothema

ISSN: 0214-9915

Year of publication: 2017

Volume: 29

Issue: 1

Pages: 35-42

Type: Article

DOI: 10.7334/PSICOTHEMA2016.86 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Psicothema

Abstract

Background: While the ethio-pathogenesis of Obsessive-Compulsive disorder (OCD) remains unknown, there is increased evidence of widespread structural alterations in both white and gray matter in OCD patients that include, but are not restricted, to abnormalities in cortico-striatal-thalamo-cortical (CSTC) regions. The objective of this study was to test the existence of structural alterations in both white and gray matter in a sample of OCD patients when compared with a group of non-clinical matched controls (NCC), using voxel-based morphometry (VBM). Method: Fifteen patients with OCD and 15 NCC underwent MRI structural scanning. Results: Frontal (increased gray matter in the middle frontal gyrus) and subcortical regions (increased white matter in the pallidum) were found to be affected in patients. Additionally, temporal-parietal regions were also found to be affected and highly correlated with OCD symptom severity (decrease of gray matter in the superior parietal lobe and white matter in the angular and superior temporal gyri). Conclusions: These alterations may be associated with prominent OCD symptoms, such as difficulties with inhibitory control (pallidum, angular gyrus), executive functioning (middle frontal gyris), compulsive checking (superior temporal gyrus) and visual-spatial deficits (superior parietal lobe).

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