A Dinuclear Gold(I)&-Silver(I) Derivative of 2-Cyclopentylidene-2-sulfanylacetic 1 Acid and Related Complexes: Synthesis, Crystal Structures, Properties and Antitumor Activity

  1. Barreiro, E. 2
  2. Casas, J.S. 2
  3. Couce, M.D. 3
  4. Laguna, A. 4
  5. López-De-Luzuriaga, J.M. 1
  6. Monge, M. 1
  7. Sánchez, A. 2
  8. Sordo, J. 2
  9. Varela, J.M. 2
  10. López, E.M.V. 3
  1. 1 Universidad de La Rioja
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    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Universidade de Santiago de Compostela
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    Universidade de Santiago de Compostela

    Santiago de Compostela, España

    ROR https://ror.org/030eybx10

  3. 3 Universidade de Vigo
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    Universidade de Vigo

    Vigo, España

    ROR https://ror.org/05rdf8595

  4. 4 Universidad de Zaragoza
    info

    Universidad de Zaragoza

    Zaragoza, España

    ROR https://ror.org/012a91z28

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Revista:
European Journal of Inorganic Chemistry

ISSN: 1434-1948

Ano de publicación: 2011

Volume: 8

Páxinas: 1322-1332

Tipo: Artigo

DOI: 10.1002/EJIC.201000959 SCOPUS: 2-s2.0-79952182387 WoS: WOS:000288099900016 GOOGLE SCHOLAR

Outras publicacións en: European Journal of Inorganic Chemistry

Resumo

The dinuclear complex [AgAu(PPh 3) 2cpa] (H 2cpa = 2-cyclopentylidene-2-sulfanylacetic acid) was prepared by treating the precursor [Au(PPh 3)(Hcpa)] with Ag(PPh 3)NO 3. The complex was characterised by spectroscopic methods (IR; 1H, 13C, 31P NMR) and mass spectrometry, and the structure was solved by a single-crystal X-ray diffraction study. Luminescence and theoretical studies were carried out, and the antitumor activity was studied in vitro against HeLa-229, A2780 and A2780cis cell lines. The related gold(I)-gold(I), [(AuPPh 3) 2cpa], and silver(I)-silver(I), [(AgPPh 3) 2cpa], compounds were also prepared and studied in the solid state and in solution. A dinuclear gold(I)-silver(I) compound was prepared and characterised, and its luminescence and cytotoxicity were studied. A comparative study with related gold(I)-gold(I) and silver(I)-silver(I) compounds was carried out in the solid state and in solution. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.