A Dinuclear Gold(I)&-Silver(I) Derivative of 2-Cyclopentylidene-2-sulfanylacetic 1 Acid and Related Complexes: Synthesis, Crystal Structures, Properties and Antitumor Activity
- Barreiro, E. 2
- Casas, J.S. 2
- Couce, M.D. 3
- Laguna, A. 4
- López-De-Luzuriaga, J.M. 1
- Monge, M. 1
- Sánchez, A. 2
- Sordo, J. 2
- Varela, J.M. 2
- López, E.M.V. 3
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1
Universidad de La Rioja
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2
Universidade de Santiago de Compostela
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3
Universidade de Vigo
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4
Universidad de Zaragoza
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ISSN: 1434-1948
Datum der Publikation: 2011
Ausgabe: 8
Seiten: 1322-1332
Art: Artikel
Andere Publikationen in: European Journal of Inorganic Chemistry
Zusammenfassung
The dinuclear complex [AgAu(PPh 3) 2cpa] (H 2cpa = 2-cyclopentylidene-2-sulfanylacetic acid) was prepared by treating the precursor [Au(PPh 3)(Hcpa)] with Ag(PPh 3)NO 3. The complex was characterised by spectroscopic methods (IR; 1H, 13C, 31P NMR) and mass spectrometry, and the structure was solved by a single-crystal X-ray diffraction study. Luminescence and theoretical studies were carried out, and the antitumor activity was studied in vitro against HeLa-229, A2780 and A2780cis cell lines. The related gold(I)-gold(I), [(AuPPh 3) 2cpa], and silver(I)-silver(I), [(AgPPh 3) 2cpa], compounds were also prepared and studied in the solid state and in solution. A dinuclear gold(I)-silver(I) compound was prepared and characterised, and its luminescence and cytotoxicity were studied. A comparative study with related gold(I)-gold(I) and silver(I)-silver(I) compounds was carried out in the solid state and in solution. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.