Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CIMUS)
Centro singular
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University of Bari Aldo Moro
Bari, ItaliaPublicacións en colaboración con investigadores/as de University of Bari Aldo Moro (43)
2024
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AI is a viable alternative to high throughput screening: a 318-target study
Scientific Reports, Vol. 14, Núm. 1
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N-Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R)
Journal of Medicinal Chemistry, Vol. 67, Núm. 13, pp. 11003-11023
2023
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Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase
Journal of Medicinal Chemistry, Vol. 66, Núm. 1, pp. 235-250
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Fluorescence based HTS-compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells
Frontiers in Molecular Biosciences, Vol. 10
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N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R)
European Journal of Medicinal Chemistry, Vol. 248
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Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction
Bioorganic and Medicinal Chemistry, Vol. 84
2022
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Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties
Molecules, Vol. 27, Núm. 4
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Design, Synthesis and 5-HT1A Binding Affinity of N-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)tricyclo[3.3.1.13,7 ]decan-1-amine and N-(3-(4-(2-Methoxyphenyl) piperazin-1-yl)propyl)-3,5-dimethyl-tricylo[3.3.1.13,7 ]decan-1-amine
MolBank, Vol. 2022, Núm. 1
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Dose-response assessment of cerebral P-glycoprotein inhibition in vivo with [18F]MC225 and PET
Journal of Controlled Release, Vol. 347, pp. 500-507
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New insights into the genetic etiology of Alzheimer's disease and related dementias
Nature genetics, Vol. 54, Núm. 4, pp. 412-436
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Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1Antagonists
Journal of Medicinal Chemistry, Vol. 65, Núm. 3, pp. 2091-2106
2021
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3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition
Journal of medicinal chemistry, Vol. 64, Núm. 1, pp. 458-480
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Evaluation of P-glycoprotein function at the blood–brain barrier using [18F]MC225-PET
European Journal of Nuclear Medicine and Molecular Imaging, Vol. 48, Núm. 12, pp. 4105-4106
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Head-to-head comparison of (R)-[11C]verapamil and [18F]MC225 in non-human primates, tracers for measuring P-glycoprotein function
European Journal of Nuclear Medicine and Molecular Imaging, Vol. 48, Núm. 13, pp. 4307-4317
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In Vivo Induction of P-Glycoprotein Function can be Measured with [18F]MC225 and PET
Molecular Pharmaceutics, Vol. 18, Núm. 8, pp. 3073-3085
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Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder
ACS Chemical Neuroscience, Vol. 12, Núm. 8, pp. 1313-1327
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Pharmacokinetic Modeling of (R)-[11C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates
Molecular Pharmaceutics, Vol. 18, Núm. 1, pp. 416-428
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Synthesis and Biological Evaluation of Dantrolene-Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases
ChemMedChem, Vol. 16, Núm. 18, pp. 2807-2816
2020
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Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R)
European Journal of Medicinal Chemistry, Vol. 188
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PET imaging of ABC transporters at the blood-brain barrier
PET and SPECT of Neurobiological Systems (Springer International Publishing), pp. 809-850