Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CIMUS)
Centro singular
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Instituto de Investigaciones Biomédicas Alberto Sols
Madrid, EspañaPublicacións en colaboración con investigadores/as de Instituto de Investigaciones Biomédicas Alberto Sols (26)
2022
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Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals
Hepatology, Vol. 75, Núm. 3, pp. 550-566
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Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue
Redox Biology, Vol. 54
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Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
Frontiers in Physiology, Vol. 13
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p38 MAPK priming boosts VSMC proliferation and arteriogenesis by promoting PGC1α-dependent mitochondrial dynamics
Scientific Reports, Vol. 12, Núm. 1
2021
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RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness
Developmental Cell, Vol. 56, Núm. 12, pp. 1727-1741.e7
2019
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New flavonoid–N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 34, Núm. 1, pp. 712-727
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TGFβ2-induced senescence during early inner ear development
Scientific Reports, Vol. 9, Núm. 1
2018
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The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca 2+ dysregulation, and mitochondrial abnormalities
Journal of Neurochemistry, Vol. 145, Núm. 2, pp. 170-182
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Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 156, pp. 534-553
2017
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Heme-Oxygenase i and PCG-1α Regulate Mitochondrial Biogenesis via Microglial Activation of Alpha7 Nicotinic Acetylcholine Receptors Using PNU282987
Antioxidants and Redox Signaling, Vol. 27, Núm. 2, pp. 93-105
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Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia
Redox Biology, Vol. 12, pp. 1040-1051
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Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease
Future Medicinal Chemistry, Vol. 9, Núm. 8, pp. 731-748
2016
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New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties
European Journal of Medicinal Chemistry, Vol. 121, pp. 376-386
2015
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Agmatine Induces Nrf2 and Protects Against Corticosterone Effects in Hippocampal Neuronal Cell Line
Molecular Neurobiology, Vol. 51, Núm. 3, pp. 1504-1519
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Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations
International Journal of Cancer, Vol. 137, Núm. 8, pp. 1870-1878
2014
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Modulation of cAMP-specific PDE without emetogenic activity: New sulfide-like PDE7 inhibitors
Journal of Medicinal Chemistry, Vol. 57, Núm. 20, pp. 8590-8607
2013
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XProgrammed cell senescence during mammalian embryonic development
Cell, Vol. 155, Núm. 5, pp. 1104
2012
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Direct promoter induction of p19Arf by Pit-1 explains the dependence receptor RET/Pit-1/p53-induced apoptosis in the pituitary somatotroph cells
Oncogene, Vol. 31, Núm. 23, pp. 2824-2835
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Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds
Journal of Medicinal Chemistry, Vol. 55, Núm. 7, pp. 3274-3284
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Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model
European Journal of Medicinal Chemistry, Vol. 47, Núm. 1, pp. 175-185