Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CIMUS)
Centro singular
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Instituto de Química Médica
Madrid, EspañaPublicacións en colaboración con investigadores/as de Instituto de Química Médica (19)
2023
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8-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studies
European Journal of Medicinal Chemistry, Vol. 248
2022
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Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors
Journal of medicinal chemistry, Vol. 65, Núm. 20, pp. 13660-13680
2021
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Biodistribution of 68/67Ga-radiolabeled sphingolipid nanoemulsions by pet and spect imaging
International Journal of Nanomedicine, Vol. 16, pp. 5923-5935
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From the Design to the in Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis
Journal of Medicinal Chemistry, Vol. 64, Núm. 9, pp. 5429-5446
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Synthesis and in vitro study of nitro- and methoxy-2-phenylbenzofurans as human monoamine oxidase inhibitors
Bioorganic Chemistry, Vol. 107
2020
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2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis
Journal of medicinal chemistry, Vol. 63, Núm. 17, pp. 9237-9257
2019
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New flavonoid–N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 34, Núm. 1, pp. 712-727
2018
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Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 156, pp. 534-553
2017
2016
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New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties
European Journal of Medicinal Chemistry, Vol. 121, pp. 376-386
2015
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3-Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases
ChemMedChem, Vol. 10, Núm. 12, pp. 2071-2079
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Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives
Bioorganic and Medicinal Chemistry Letters, Vol. 25, Núm. 3, pp. 642-648
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The melatonin- N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer's model via hemo-oxygenase-1 induction
ACS Chemical Neuroscience, Vol. 6, Núm. 2, pp. 288-296
2014
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Modulation of cAMP-specific PDE without emetogenic activity: New sulfide-like PDE7 inhibitors
Journal of Medicinal Chemistry, Vol. 57, Núm. 20, pp. 8590-8607
2013
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Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities
European Journal of Medicinal Chemistry, Vol. 70, pp. 781-788
2012
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Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds
Journal of Medicinal Chemistry, Vol. 55, Núm. 7, pp. 3274-3284
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Identification in Silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice
ACS Chemical Neuroscience, Vol. 3, Núm. 10, pp. 793-803
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Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model
European Journal of Medicinal Chemistry, Vol. 47, Núm. 1, pp. 175-185
2000
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Synthesis and pharmacological evaluation of 2,3-dihydro-3-oxo-4H- thieno[3,4-e][1,2,4]thiadiazine 1,1-dioxides as voltage-dependent calcium channel blockers
European Journal of Medicinal Chemistry, Vol. 35, Núm. 7-8, pp. 751-759