Molecular Medicine and Chronic Diseases Research Center (CIMUS)
Singular centre
Juan
Roa Rivas
Publications by the researcher in collaboration with Juan Roa Rivas (36)
2022
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Connecting nutritional deprivation and pubertal inhibition via GRK2-mediated repression of kisspeptin actions in GnRH neurons
Metabolism: Clinical and Experimental, Vol. 129
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Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice
Nature communications, Vol. 13, Núm. 1, pp. 4663
2021
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AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction
Metabolism: Clinical and Experimental, Vol. 115
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Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation
Nature Metabolism, Vol. 3, Núm. 10, pp. 1415-1431
2020
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Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty
Cell Metabolism, Vol. 32, Núm. 6, pp. 951-966.e8
2019
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Gonadal hormone-dependent vs. -independent effects of kisspeptin signaling in the control of body weight and metabolic homeostasis
Metabolism: Clinical and Experimental, Vol. 98, pp. 84-94
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Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3
PLoS Biology, Vol. 17, Núm. 11
2018
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Intergenerational Influence of paternal obesity on metabolic and reproductive health parameters of the offspring: Male-preferential impact and involvement of kiss1-mediated pathways
Endocrinology, Vol. 159, Núm. 2, pp. 1005-1018
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Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling
Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Núm. 45, pp. E10758-E10767
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SF1-specific AMPKa1 deletion protects against diet-induced obesity
Diabetes, Vol. 67, Núm. 11, pp. 2213-2226
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SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
Nature Communications, Vol. 9, Núm. 1
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Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its Congenital Ablation in mice
Metabolism: Clinical and Experimental, Vol. 87, pp. 87-97
2017
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Development and validation of a method for precise dating of female puberty in laboratory rodents: The puberty ovarian maturation score (Pub-Score)
Scientific Reports, Vol. 7
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Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance
Cell Metabolism, Vol. 26, Núm. 1, pp. 212-229.e12
2016
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Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of puberty
Molecular Metabolism, Vol. 5, Núm. 10, pp. 844-857
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Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity
Scientific Reports, Vol. 6
2015
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Metabolic and gonadotropic impact of sequential obesogenic insults in the female: Influence of the loss of ovarian secretion
Endocrinology, Vol. 156, Núm. 8, pp. 2984-2998
2014
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Hypothalamic mTOR: The rookie energy sensor
Current Molecular Medicine, Vol. 14, Núm. 1, pp. 3-21
2012
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Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism
Journal of Pathology, Vol. 227, Núm. 2, pp. 209-222
2010
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The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat
Journal of Neuroscience, Vol. 30, Núm. 23, pp. 7783-7792