Publicacións en colaboración con investigadores/as de Instituto de Química Médica (17)

2023

  1. 8-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studies

    European Journal of Medicinal Chemistry, Vol. 248

2022

  1. Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors

    Journal of medicinal chemistry, Vol. 65, Núm. 20, pp. 13660-13680

2021

  1. From the Design to the in Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis

    Journal of Medicinal Chemistry, Vol. 64, Núm. 9, pp. 5429-5446

  2. Synthesis and in vitro study of nitro- and methoxy-2-phenylbenzofurans as human monoamine oxidase inhibitors

    Bioorganic Chemistry, Vol. 107

2020

  1. 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis

    Journal of medicinal chemistry, Vol. 63, Núm. 17, pp. 9237-9257

2019

  1. New flavonoid–N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

    Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 34, Núm. 1, pp. 712-727

2018

  1. Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease

    European Journal of Medicinal Chemistry, Vol. 156, pp. 534-553

2017

  1. Targeting PDE10A GAF domain with small molecules: A way for allosteric modulation with anti-inflammatory effects

    Molecules, Vol. 22, Núm. 9

2016

  1. New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

    European Journal of Medicinal Chemistry, Vol. 121, pp. 376-386

2015

  1. 3-Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases

    ChemMedChem, Vol. 10, Núm. 12, pp. 2071-2079

  2. Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives

    Bioorganic and Medicinal Chemistry Letters, Vol. 25, Núm. 3, pp. 642-648

2014

  1. Modulation of cAMP-specific PDE without emetogenic activity: New sulfide-like PDE7 inhibitors

    Journal of Medicinal Chemistry, Vol. 57, Núm. 20, pp. 8590-8607

2013

  1. Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities

    European Journal of Medicinal Chemistry, Vol. 70, pp. 781-788

2012

  1. Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

    Journal of Medicinal Chemistry, Vol. 55, Núm. 7, pp. 3274-3284

  2. Identification in Silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice

    ACS Chemical Neuroscience, Vol. 3, Núm. 10, pp. 793-803

  3. Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

    European Journal of Medicinal Chemistry, Vol. 47, Núm. 1, pp. 175-185

2000

  1. Synthesis and pharmacological evaluation of 2,3-dihydro-3-oxo-4H- thieno[3,4-e][1,2,4]thiadiazine 1,1-dioxides as voltage-dependent calcium channel blockers

    European Journal of Medicinal Chemistry, Vol. 35, Núm. 7-8, pp. 751-759